Covid/Climate Prigs Are Out to Spoil Your Days

Christopher Gage writes at Oxford Sour Bay of Prigs.  Excerpts in italics with my bolds.

Enamoured by lockdown, the puritans wish for a perma-pandemic in which no-one, nowhere, will be happy.

Not content with dying their hair green and punching steel through their nostrils, progressives here in Great Britain have proposed something rather more exquisitely demented than their usual fare.

The Independent, a kind of Guardian for actors manqué and Cluster B personalities, those who suffer from fictitious ailments of which ‘the doctor doesn’t know what’s wrong,’ asks, ‘Should Everyone Have a Personal Carbon Quota?’

Helpfully, the newspaper lays out exactly what a Carbon Quota would entail.

It begins: “Your home, sometime in the next decade. You click the heating on and receive an app notification telling you how much of your carbon allowance you’ve used today.

“Outside in the drive, your car’s fuel is linked to the same account. In the fridge, the New Zealand lamb you’ve bought has cost not just pounds and pence but a chunk of this monthly emissions budget too.

“Welcome to the world of personal carbon allowances – a concept that is increasingly gaining traction among experts as a possible response to the climate crisis.”

Curiously, this all sounds like one’s entire life would be recorded and regulated and monitored and meddled with by politicians who’ll punish or praise, all in pursuit of a vague utopia. Sounds familiar.

According to my Carbon Quota, I could live happily and healthily, provided I die next Tuesday at noon.

If I were to stay on this planet and offend Mother Nature with my presence, I’d have to limit myself to half a cigarette per day, a slither of ribeye per week, and one soupçon of red wine per month. Such a paltry regimen would dissolve around 90% of my personality.

Besides, Tuesday is no day to die. Especially before the 4 p.m. happy hour.

Perhaps, I could time it just right. I’ll prop up a stool in my favourite dive bar, and impart everything I’d like to say but avoid saying in fear of social ostracization.

I could say that there is a biological reason why women aren’t funny. I could say that, on balance, the British Empire was a good thing, and that anyone whinging about ‘cultural appropriation’ seldom has any culture worth appropriating. I could say, with conviction, that the Jews obviously don’t secretly run the world because if they did, the world would be far closer to utopia than it is now. I could suggest that those who play music on public transport, indeed—in public—should be hung, drawn, and quartered for the benefit of the gene pool. I could say all this before shuffling off into the light.

(If my girlfriend—whose people have won a fifth of all Nobel Prizes despite being 0.2% of the world population—objects, then I’m sorry… I’m saving the planet, darling.)

You can define the confidence of a culture by the pettiness of its laws.

I’d rather shuffle off than live in a world in which one’s social status is tied to one’s ability to pretend falafel is edible, to one’s withering body. I’d rather that than live in a world in which the prigs and puritans, those weird kids from school with ‘Free Da Weed’ Sharpied on their hemp rucksacks, have won the final victory over everyone else. A world in which every consideration is now suffixed with ‘to save the planet.’

We shouldn’t feign surprise. A stubborn one-third of any population harbours latent authoritarian tendencies. All they need is a little nudge and a wink from someone in a lab coat or a pinstripe suit.

Over the last twenty months, we’ve given them plenty to chew on. We’ve sacralised Crab Mentality—that depressingly human tendency to pull down others into the soup of conformity. For many, this pandemic has been the time of their lives. They’ve enjoyed grassing on neighbours, posting their vaccine statuses, their three-mask chic. Don’t mention that sensible Sweden got it right. Don’t mention that lockdown only delays the inevitable, to great human cost. Don’t mention the fatal link between obesity and Covid deaths.

They’d love life in Austria, where the government has mandated a Western first—forcible vaccination for every citizen.

What a time to be alive. This pandemic has valorised negative personality traits. Back in the Old Normal, high neuroticism combined with high agreeableness meant you’d spend your days siphoning your biography for ‘trauma’ to weaponize against the world. Now, it’s a plus. Like Woke intellectuals, the neurotics mistake their personal problems for societal problems.

I assumed a majority of Britons would, like me, rather chew on a glass vial labelled ‘Wuhan Institute of Virology,’ than consider medical apartheid. Nope.

According to YouGov, six in ten Britons support the introduction of a ‘papers, please’ society—vaccine passports.

That’s despite vaccines blunting Covid’s ability to hospitalise and kill, but not its ability to spread—rendering vaccine passports both pointless and poisonous.

Of course, the usual disclaimer applies just in case anyone of a progressive bent is reading: I’m not saying it’s Nazi Germany, but it’s quite clear how totalitarian regimes slip into power with little resistance.

A recent survey in The Economist made for terrifying reading: forty percent wanted masks forever; a quarter wanted to shut down nightclubs and casinos; another third wanted socially-distanced pubs and clubs and theatres; a hefty rump wanted a 10 p.m. curfew, and one-third said anyone coming into this country should be quarantined, like a dog, for ten days. And they wanted all this lunacy indefinitely, Covid or not.

Perhaps that explains why the eco-loons can air with confidence the drudgery they wish to impose upon everyone else. Not a day goes by without some middle-class Insulate Britain bobo blocking the motorway or making ‘demands’ upon the government to act on the ‘climate crisis’.

What nobody asks is how any of this nonsense would make any difference given that Great Britain contributes less than one percent of global carbon emissions. Those who follow The Science don’t cotton on when last week’s gospel morphs into this week’s heresy.

What happens when we reach Net Zero and the weather doesn’t change? I can only guess… ‘That wasn’t real Net-Zero. Real Net-Zero has never been tried.’

They don’t ask such obvious questions because the answer is obvious: they don’t care about all that. As Mencken wrote, they’re governed by the haunting fear that someone, somewhere, may be happy.

That’s the problem with do-gooding. There’s always more good to do.

 

Tokyo Stops Covid With Ivermectin

Dr, Pierre Kory tweets: Tokyo in particular is kicking COVID’s ass with IVM – fewest hospitalized since before pandemic. Come on world, wake up wake up wake up

Background from  Previous Post 

In February 2021, Dr. Ozaki Chairman of the Tokyo Medical Association declared that Japan’s physicians should get a greenlight to prescribe IVM (Ivermectin) at the first sign of SARS CV infections.

Now in August, Tokyo Medical Association chairman Haruo Ozaki reiterated that ivermectin should be widely used and said that his early recommendations have not been heeded in Japan.  See Lifesite article August 30, 2021 Japanese medical chairman doubles down on ivermectin support after early calls went ignored.  Excerpts in italics with my bolds

In an interview with the The Yomiuri Shimbun on August 5, Ozaki spoke in detail about his opinion that ivermectin should be used in Japan and said that his early calls for usage have seemingly not been heeded.

He stated that there is evidence from multiple countries that ivermectin has proven effective for patients diagnosed with COVID: “I am aware that there are many papers that ivermectin is effective in the prevention and treatment of [coronavirus], mainly in Central and South America and Asia.”

Chairman Ozaki stated that despite evidence suggesting the efficacy of ivermectin, it is difficult to obtain the medication. He added that while ivermectin’s established effectiveness is increasingly clear, the U.S. company that manufactures the drug, Merck & Co., Inc., have currently limited distribution because they claim that the drug is ineffective at treating COVID.

“With the view that it is not effective for the treatment and prevention of sickness, there is an intention that it should not be used for anything other than skin diseases such as psoriasis.”

This has led to a situation where, according to Ozaki, “Even if a doctor writes a prescription for ivermectin, there is no drug in the pharmacy.” He said that this has rendered the drug practically “unusable.”

He contends that the fact that supply has been stopped by Merck & Co. is evidence that it does in fact work at treating COVID: “But (Merck) says that ivermectin doesn’t work, so there shouldn’t be any need to limit supply. If it doesn’t work, there’s no demand. I believe it works, so block supply. It looks like you are.”

He said that he “also told the Japan Olympic Committee that ivermectin should be used effectively when holding the Tokyo Olympics. But the government didn’t do anything.”

He addressed the reluctance on behalf of the medical establishment in using ivermectin to treat COVID. He said “there are problems for researchers in academia and professors in universities. Many do not do anything by themselves, but they are of the opinion of international organizations such as the WHO and large health organizations in the United States and Europe that ‘it is not yet certain whether ivermectin will work for the [coronavirus].’”

“We don’t do it on our own initiative, but only on the opinions of others. Why don’t we try to see for ourselves why ivermectin works? It is deplorable that there are critics, researchers, and scholars who are constantly criticizing without doing anything. I hope that Japanese academics will contribute more actively.”

Evidence that ivermectin is effective in treating COVID has been well attested in developing nations where vaccines are not widely distributed. Another study in France also suggested that ivermectin ought to be used as a remedy for COVID.

On May 25, the Indian Bar Association served a legal notice to Dr. Soumya Swaminathan, a Chief Scientist for the World Health Organization (WHO), relating to the harm she allegedly caused the people of India by campaigning against the use of ivermectin.

In Mexico city, a home-treatment-kit, including ivermectin was created, for its 22 million-strong population on December 28, 2020, following a spike in cases of COVID-19. Also, doctors were encouraged to use Ivermectin and other therapeutic drugs in their practice when dealing with COVID-positive patients. The effort resulted in a 52–76 percent reduction in hospitalizations, according to research by the Mexican Digital Agency for Public Innovation (DAPI), Mexico’s Ministry of Health, and the Mexican Social Security Institute (IMSS).

Following that came a public statement by another prominent Japanese physician, Dr. Kazuhiro Nagao, who appeared on Japanese television proposing that COVID-19 should be treated as a Class 5 illness as opposed to its current classification as a Class 2. In Japan, illnesses are categorized by a classification system; approaching COVID as a Class 5 illness would mean that it could be treated like a seasonal flu.

Dr. Nagao said he has used Ivermectin as an early treatment for over 500 COVID patients with practically a 100% success rate, and that it should be used nationwide.

About the effectiveness of Ivermectin in treating COVID patients, he said: “It starts being effective the very next day… My patients can reach me by message 24/7 and they tell me they feel better the next day.”

Nagao was asked by the TV anchor when patients should take Ivermectin if diagnosed with COVID-19. He replied: “The same day, I mean if you are infected today, you take it today… It is a medication that should be given for mildly ill patients. If you give it to hospital patients, it’s too late. This is also the case for the majority of drugs… So you have to give Ivermectin. I am asking our Prime Minister Suga to distribute this drug ‘made in Japan’ on a large scale in the country.

He added that four pills should be distributed to everyone in the country, so that people can take them “as soon as you are infected.”

Footnote: 

As Dr. Ozaki suggests Big Pharma wants to banish any treatments that are cheap and effective. Doing the math:

An Ivermectin course for COVID is less than twenty dollars.

A course of REMDESEVIR is currently right at $8800.00 dollars. (and often doesn’t work)

An outpatient treatment with monoclonal antibodies is right at $23,000.00 – 25,000.00 dollars with all the infusion costs added.

That’s not to mention obscene vaccine profits.

How Voter Fraud Is Revealed in 35 US States

Jay Valentine reports on the behind-the-scenes canvassing organizations documenting widespread fraud in the 2020 elections.  Surprisingly, even in states carried handily by Trump, there were large numbers of illegal ballots counted in state and local races.  His article at American Thinker is Meet the Technology That’s Uncovering 2020’s Voter Fraud.  Excerpts in italics with my bolds and images.

Were You a Phantom Voter?  Now You Can Find Out.

The search for phantom voters is over. Phantom voters are sitting next to you at the restaurant or standing next to you at the bank. They are your friend and neighbor. You may be a phantom and not know it.

Phantom voters, the definition, is morphing from fake voters hiding in UPS boxes to people who advanced computer models predict will not vote.

Don’t get me wrong — there are thousands of phantom voters living in churches, R.V. parks, cemeteries, homeless shelters, hotels, and virtual mailboxes. It’s just that there are as many, perhaps more, who live active, healthy, honest lives on voter rolls. They just don’t know they voted.

You’ve heard the stories, denied by the mainstream press and almost every secretary of state: “there is no significant voter fraud.” Why not say that? There is no way you can check.

Now there is.

After the 2020 election results stopped in the middle of night and vote trajectories magically changed when they fired up again, thousands of people, just like you, didn’t buy it. They formed armies of canvassers in 35 or more states. They did something that has not been done at scale in the history of the country: they started checking voter rolls.

They did more. They filed Freedom of Information Act (FOIA) requests at unprecedented levels. Secretary of state offices, once a murky sinecure, had to answer real questions about what was going on.

Here’s what popped out.

Leftists are different from you and me. Unlike us, they care that every vote is cast, and if you do not cast your vote, they will do it for you. And they did. At scale.

In one midwestern state, voter rolls costing tens of thousands of dollars were bought by a billionaire leftist every month for over a year. Why would someone buy a list that doesn’t change much?

Voter lists show people who move. They show people who never or seldom vote.

The white hat canvassing team built a query for one state: “voters who voted in 2020 who never voted before.” Guess what! 265,000.

In the same state, thousands of people came forward with stories that when they showed up to vote, they were told someone had voted for them. Get the picture?

In a southwestern state, in its second largest city, there was a 21-day daily tabulation of cast ballots. Once a ballot is cast, it should not be changed. Not here.

When the millions of cast votes across over 21 snapshots were compared, thousands of ballots had been altered. Some were minor alterations, like a slight name change. Others were more interesting — like when someone voted in person, but his vote was later changed by an absentee ballot.

It gets better.

Those FOIA requests are mining gold. Our midwestern state has documents showing that the state election organization gave online access to a leftist group for weeks during the voting. Citizens had to pay over $20,000 for one shapshot of the voter roll. Leftists could, and did, access it online throughout the process. For free.

And access it they did. Witness statements are being gathered, lots of them, that in the largest city, election officials were trading cell calls about how many votes were needed, and someone was then providing the phantoms to meet the quota.

They knew the names of the phantoms — they had direct access to who voted, who didn’t, and who was likely to never show up.

This is not exclusively a blue-state phenomenon.

In a deep red state, canvassers found more traditional phantoms.

There were the 21 people at the fraternity house. Nothing to see here — until they sorted them by age. All these kids were active voters, many voted, and their age range was from 115 to 57. Some frat house.

These red-state canvassers went deeper. They showed that the phantoms did not vote en masse in the 2020 presidential election. Phew! Feeling better. But wait. They vote in droves in state, county, municipal elections.

Aha — here was another interesting pattern, never seen before.

This deep red state that voted for Trump by double-digit margins did not call out its phantom army when it could not move the needle. When local, state elections were up, well, those people voted — even the 21 at the county jail and the 41 registered at the Recreation Commission.

In earlier American Thinker articles, we created the phrase “sovereign fraud.” That means your government is in on it.

As more than 35 state citizen organization now are using the most advanced search and big data technology to look into voter rolls, and cross-check them with churches, R.V. parks, fictitious street locations, they are concluding the office of secretary of state is corrupt, incompetent, or often both.

Let’s take incompetent.

In about every state, there are voters old enough to have fought in the Civil War, and they still vote. In one state, there are voters — a bunch of them older than Julius Caesar — the Roman guy.

States have voter rolls with multiple people using the same voter ID. When pressed, they have some screwy excuse that it’s a sequencing anomaly. At least one state adds every new voter to the end of its voter ID sequence, as one would expect. Except when it doesn’t. These people have numbers that skip by two and later ten, and they insert voters there, not at the end.

There are hundreds I have personally seen, thus thousands in every state — examples of 16 people, with different last names, living in that one-bedroom, 876-square-foot house. Really?

Let’s go to corrupt.

Secretaries of state, when pressed to cough up those voter rolls, after the confiscatory price is paid, change the data in such a way that it cannot be searched with traditional technology. Tough luck for them; our canvassing friends have search technology five generations ahead, so it gets done.

Canvassers in 35 or more states are digging, and the more they find, the more relentless they become. We are pleased to provide technology that runs a thousand times faster than anything available to any secretary of state or leftist voter fraud group.

These canvassing organizations are the Minutemen of this generation. They come from every background, organize with no central leadership. They blindly figured out how phantom voting was happening, and they are forcing states to audit their voter rolls.

They aren’t blind anymore. They are organized. They have resources and technology, and things are about to change in a big way for phantoms.

 

 

Economics of Infrastructure Investment

Mathew Kahn discusses the ramifications of the major transportation spending recently passed by the US Congress. Of course, as the pie chart shows, infrastructure as many people think of it—construction or improvement of bridges, highways, roads, rail and subways, ports, waterways, and airports—accounts for only $157 billion, or 7%, of the plan’s estimated cost.  Still that is a lot of money (“A billion here, a billion there, and soon it adds up to real money”–US Senator), and Kahn provides a list of concerns in his article What Insights Does Economics Offer About the Nascent Biden Administration Transport Infrastructure Investment Program?   Excerpts in italics with my bolds and images.

The Washington Post has published a piece stating that the Secretary of Transportation, Peter Buttigieg, is the big winner of the Biden Infrastructure Bill as he will be attending many ribbon cutting ceremonies as grateful local mayors shake his hand.

Economic research offers many insights here about the efficiency and equity effects of this multi-billion dollar investment.

Point #1: This is an irreversible investment. When a city builds a new subway line, this billion dollar project cannot be later sold on Ebay and use the $ to do something else. In contrast to light rail and subway lines, dedicated buses feature more option value because they can be sold off or redeployed on different routes in the same city. Given that we don’t know how cities will develop over time, this real option has value.

Point #2; Past expansions of public transit have not significantly increased ridership with the exception of Washington DC. In the case of Los Angeles, improves in rail service (such as the Light Rail on Exposition that I ride) has taken bus riders away from the bus. See our 2005 paper. If crime rates continue to be a concern in cities then the middle class will be even less likely to use the “shiny new” infrastructure. The poor do rely on public transit to move around cities and an expansion will improve their quality of life. An economist would ask whether they value this benefit more than the cash equivalent?

Point #3: The older infrastructure in the nation is located in older cities, where the population is barely growing (or shrinking) and where the voters are mainly Democrats.

Point #4: The highways tend to be built in the suburbs where the voting base leans Republican. My 2011 Brookings piece with David offers several constructive ideas for how to “build back better” here.

Point #5: If progressive cities gain better infrastructure due to the Biden Investment AND if they don’t build much housing (the progressive city NIMBYism is well documented) , then housing prices will rise and the poor and middle class will be further squeezed by this new investment.

Point #6: There are many economics consulting firms that intentionally offer extremely optimistic ridership estimates ex-ante and this helps ambitious government officials to justify projects (i.e to say that it passes a cost/benefit test) when in reality — ex-post evaluations show low usage of the new infrastructure. See Pickrell 1992.

Point #7: Given that unions are powerful in progressive cities, what is the marginal cost of infrastructure creation in these cities? Is the Department of Transportation seeking to build a new capital stock or to enrich a special interest group that supports the Democrats? How many middle class new construction jobs will be created? Will the expansion of the public capital stock crowd out the expansion of the private capital stock as construction crews work on transport infrastructure rather than building private sector projects? What is the shape of the construction supply curve?

Point #8, once the new infrastructure is completed — will this greatly improve urban quality of life in cities such as Baltimore that have been shrinking? How will the Mayor and local civic leaders and private sector stakeholders change their investments and policy decisions? What positive synergies might emerge? Our 2021 Unlocking Book explores some of these themes of investment co-ordination between the private and the public sector.

IVM Beats Pfizer and Merck One-Trick-Pony Pills

 

Hypothetical model illustrating the inhibition of SARS-CoV-2 replication by ivermectin mediated through the blocking of α/β1-importin (imp) as well as 3CLpro enzymatic activity. Mody et al (2021)

John Campbell explains in the video below how the new Pfizer pill copies one trick from Ivermectin, without IVM’s other anti-viral mechanisms, resulting in an inferior and dangerous medicine.  I have transcribed the basic message along with excerpts and links to several papers to which he refers. Excerpts are in italics with my bolds.

Pfizer’s new antiviral drug PAXLOVID™ shows very high levels of efficacy in preventing serious disease hospitalization and people dying.  And that drug works in a particular way, what we call a pharmacodynamic action.

But there’s another generic drug called Ivermectin that you might have heard of that works in exactly the same way as that. Now no one’s saying that information has been deliberately suppressed for years while millions of people have died but what we are going to show on this video is conclusive proof from the literature that this modality of action is the same.

How Coronavirus Infects Its Host

Before we crack into that we need to look at what’s happening so when a virus, in this case coronavirus2 gets into a cell. What happens is it makes lots of proteins. It starts off making  these long proteins, out of hundreds of amino acids sometimes. A few thousand amino acids all strung together.

The problem is they’re too long for the job that’s required. So it’s a bit like a building site and when a big log of wood arrives it needs to be trimmed down into bits that fit in your door frames and your window frames. So these proteins need to be trimmed down and it has to be done in a biochemical way.

In the case of coronavirus two, there’s an enzyme called 3CL protease which breaks
down protein into smaller pieces. it’s what we call proteolytic and it will take these long proteins and it will chop them into shorter proteins it’s what we call an endopeptidase. So now instead of having one long protein we’ve got two short ones and these fit together just nicely for the new virus that we’re we’re trying to make.

These new drugs are what we call protease inhibitors because they stop the protease from working. If the protease is like this scissor, the inhibitor is like this tape stopping the cutting up of long proteins.

When there’s another long protein that needs to be processed the 3CL protease comes along ready to chop this up. But now these drugs have bounded up the active site of the protease and they stop the protease from chopping up the big proteins into smaller strings of amino acids. Since they can’t build the virus, it inhibits viral replication.

This is the new Pfizer drug which is designed to block the activity of the sars coronavirus2 3CL, so that 3CL protease now won’t work. It won’t open so i can’t chop my proteins into the correct length to build a nice new virus.   And of course a 3CL protease inhibitor will stop it from making sars coronavirus2 and is therefore anti-viral.

Everyone in human biology has heard of chymotryptin. It’s an enzyme released by the pancreas to digest protein. It’s a protein chopping up enzyme so this chymotryptin-like protease inside the virus is working in a very similar way to the chimbotryptin that your pancreas produces to digest your proteins.

Evidence from Pfizer News Release

Pfizer’s novel COVID-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR study.

  • PAXLOVID™ (PF-07321332; ritonavir) was found to reduce the risk of hospitalization or death by 89% compared to placebo in non-hospitalized high-risk adults with COVID-19
  • In the overall study population through Day 28, no deaths were reported in patients who received PAXLOVID™ as compared to 10 deaths in patients who received placebo
  • Pfizer plans to submit the data as part of its ongoing rolling submission to the U.S. FDA for Emergency Use Authorization (EUA) as soon as possible.

If approved or authorized, PAXLOVID™, which originated in Pfizer’s laboratories, would be the first oral antiviral of its kind, a specifically designed SARS-CoV-2-3CL protease inhibitor. Upon successful completion of the remainder of the EPIC clinical development program and subject to approval or authorization, it could be prescribed more broadly as an at-home treatment to help reduce illness severity, hospitalizations, and deaths, as well as reduce the probability of infection following exposure, among adults. It has demonstrated potent antiviral in vitro activity against circulating variants of concern, as well as other known coronaviruses, suggesting its potential as a therapeutic for multiple types of coronavirus infections.

Evidence for 3CL protease inhibitors from September 2020

Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening Zhu et al. (Sept 3, 2020)

Viral protease is a valid antiviral drug target for RNA viruses including coronaviruses. (13) In response to the COVID-19 pandemic, great efforts have been made to evaluate the possibility of repurposing approved viral protease inhibitor drugs for the clinical treatment of the disease. Unfortunately, the combination of lopinavir and ritonavir, both approved HIV protease inhibitors, failed in a clinical trial without showing benefit compared to the standard of care. (14) To address this unmet need, several virtual screens and a drug repurposing screen were performed to identify SARS-CoV-2 3CLpro inhibitors.

In conclusion, this study employed an enzymatic assay for qHTS that identified 23 SARS-CoV-2 3CLpro inhibitors from a collection of approved drugs, drug candidates, and bioactive compounds. These 3CLpro inhibitors can be combined with drugs of different targets to evaluate their potential in drug cocktails for the treatment of COVID-19. In addition, they can also serve as starting points for medicinal chemistry optimization to improve potency and drug-like properties.

Ivermectin Emerges as Top Antiviral Candidate for CV2

Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents Mody et al. (2021), source of diagram at top. Excerpts in italics with my bolds.

Fig. 4: Ivermectin exhibited complete inhibition of SARS-CoV-2 3CLpro enzymatic activity whereas micafungin partially inhibited the enzyme.

The off-target drugs that are being used to treat non-viral ailments selected by in silico studies were screened for their inhibitory activity against SARS-CoV-2 3CLpro enzyme.

Interestingly, one of the OTD (Off Target Drugs), ivermectin was able to inhibit more than 85% (almost completely) of 3CLpro activity in our in vitro enzymatic assay with an IC50 value of 21 µM. These findings suggest the potential of ivermectin to inhibit the SARS-CoV-2 replication. In support of this, a recent finding suggested that ivermectin (5 µM) inhibited the replication of live SARS-CoV-2 isolated from Australia (VIo1/2020) in Vero/hSLAM cells23. They found that >5000-fold viral counts were reduced in 48 hr in both culture supernatant (release of new virion: 93%) as well as inside the cells (unreleased and unassembled virion: 99.8%) when compared to DMSO treated infected cells.

Earlier studies have demonstrated that the possible anti-viral mechanism of ivermectin was through the blockage of viral-protein transportation to the nucleus by inhibiting the interaction between viral protein and α/β1 importin heterodimer, a known transporter of viral proteins to the nucleus especially for RNA viruses19,20,21,22,23. However, in this study, we have reported that ivermectin inhibits the enzymatic activity of SARS-CoV-2 3CLpro and thus may potentially inhibit the replication of RNA viruses including SARS-CoV-2. These studies suggest that ivermectin could be a potential drug candidate to inhibit the SARS-CoV-2 replication and the proposed anti-viral mechanism of ivermectin presented in Fig. 8 and in vivo efficacy of ivermectin towards COVID-19 is currently been evaluated in clinical trials (ClinicalTrials.gov Identifier: NCT04438850).

Ivermectin Strong Against Multiple Targets

Inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study.  Excerpts in italics with my bolds.

Double-click on image to enlarge.

In conclusion, both ivermectin and remdesivir could be considered potential drugs for the treatment of COVID-19. Ivermectin efficiently binds to the viral S protein as well as the human cell surface receptors ACE-2 and TMPRSS2; therefore, it might be involved in inhibiting the entry of the virus into the host cell. It also binds to Mpro and PLpro of SARS-CoV-2; therefore, it might play a role in preventing the post-translational processing of viral polyproteins. The highly efficient binding of ivermectin to the viral N phosphoprotein and nsp14 is suggestive of its role in inhibiting viral replication and assembly. Remdesivir may be involved in inhibiting post-entry mechanisms as it shows high binding affinity to N and M proteins, PLpro, Mpro, RdRp, and nsp14. Although the results of clinical trials for remdesivir are promising (Beigel et al., 2020; Wang Y. et al., 2020), similar clinical trials for ivermectin are recommended. Both these drugs exhibit multidisciplinary inhibitory effects at both viral entry and post-entry stages. Source: Molecular Docking Reveals Ivermectin and Remdesivir as Potential Repurposed Drugs Against SARS-CoV-2

Conclusion from John Campbell

So whereas the Pfizer drug is only working as far as we’ve been told in the proviso press release against one biochemical modality of viral replication, the Ivermectin mechanism is working at many different levels. The fact that the the the Pfizer medicine is only working against one particular biochemical pathway means to me that the virus could learn to avoid that. It could evolve to be drug resistant as indeed the early antiretrovirals did with HIV.

With ivermectin, because it’s working on so many different levels, it is improbable, to put it mildly,that a virus would mutate in a dozen different ways to avoid all those different mechanisms. We’ve talked about six mechanisms today. It’s very unlikely that we get six mutations that could dodge all of those all at the same time.

So I’ve a brief message to world leaders, people that are making the decisions about this. Come on you all, you’re not a horse and you’re not a cow. You’ve got a human intellect. Let’s use it to follow the scientific evidence to save human pain, suffering and death.

Footnote:  This video focused on Pfizer’s pill, but Merck’s Molnupiravir pill is also a one-trick-pony.  See Why Merck Dissed Its Own Invention Ivermectin

 

 

 

 

 

 

 

If CV Vaccines Work, Why Aren’t They Working?

The issue is discussed by Brian C. Joondeph, M.D. in his American Thinker article If the Vaccines Work, Why Aren’t They Working? Excerpts in italics with my bolds.

In the movie Moneyball, Oakland Athletics general manager Billy Beane queries his team of scouts when discussing a prospective player, “If he’s a good hitter, why doesn’t he hit good?” The scouts all have solid explanations, at least in their minds, of why a prospect might be a good hitter, from the sound of the crack of the bat when they hit the ball to the player’s good looks.

These explain why the player should be a good hitter, but what if the numbers, from batting average to on-base percentage, tell a different story? The question Billy poses is obvious in its simplicity, good hitters should hit good. And if they don’t, then perhaps they are not really good hitters.

What if we ask the same question about COVID vaccines, rephrased as “If the vaccines work, why aren’t they working?”

This is the time when I must add the necessary disclaimer that I am not anti-vaccine, having been personally fully vaccinated almost a year ago. Nor am I offering medical advice, only an analysis of current news of COVID cases rising in many highly vaccinated locales, seemingly against common sense.

Some readers have asked why such a disclaimer is necessary. I am a practicing physician, although I don’t treat COVID patients, administer vaccines, or offer medical advice regarding COVID to my retina patients. But today, just having an opinion can be hazardous to one’s livelihood.

The American Federation of Medical Specialists makes it clear, “Physicians who generate and spread COVID-19 vaccine misinformation or disinformation are risking disciplinary action by state medical boards, including the suspension or revocation of their medical license.”

Hopefully asking thoughtful questions and observing how the medical authorities like Dr. Anthony Fauci have changed their own positions on vaccines is not considered “misinformation.” Or that citing the CDC and major news organizations won’t be considered “disinformation.” In the 1950s, x-raying pregnant women was standard practice, and questioning that harmful procedure, were such a thing to be done in the 1950s with today’s climate now might be considered mis- or disinformation.

If you think such medical censorship is all conspiracy theory, ask Dr. Mary Bowden, a Houston ear, nose, and throat specialist suspended from her Houston hospital for tweeting about vaccine mandates and ivermectin.

Back to COVID vaccines: “Safe, Effective and Free”

The CDC website states, “COVID-19 vaccines are safe, effective, and free.” Those three words are all relative. Let’s quickly unpack them.

CV Vaccine Safety

VAERS is the “Vaccine Adverse Event Reporting System.” From their website, one can compare adverse events from COVID vaccines from the past 11 months they have been available to adverse events from all vaccines for the past 30 years, 1990 and onward.

Note this is 11 months versus 30 years of side effects and in most categories, the cumulative cases are similar between the two groups, despite a 30-fold time difference of data recording. Of note, hospitalizations, deaths, permanent disabilities, and birth defects were greater for 11 months of COVID vaccines than they were for 30 years of all other types of vaccines – such as shingles, influenza, measles, mumps, hepatitis, and so on.

VAERS is voluntary reporting. For a variety of reasons, all cases do not make it to the VAERS database. How much is this underreporting? VAERS did their own analysis about ten years ago and found, “Fewer than 1% of vaccine adverse events are reported.” Their words, not mine.

This means adverse events could be happening far more frequently than what we are being told by the corporate media who don’t even report VAERS’s current data. What if these adverse events are 10 or even 100 times more common than VAERS reports? To paraphrase Billy Beane, “If the vaccines are safe, why aren’t they safe?”

CV Vaccine Effectiveness

Are they effective? The CDC answers an emphatic yes,

COVID-19 study shows mRNA vaccines reduce risk of infection by 91 percent for fully vaccinated people. Vaccination makes illness milder, shorter for the few vaccinated people who do get COVID-19.

Does the real world agree and support the CDC’s optimism? Gibraltar is more than fully vaccinated, they are 118 percent vaccinated, meaning that many fully vaccinated have had booster injections too. Yet this headline doesn’t jive with CDC assertions, “Most vaccinated place on Earth told to cancel holiday plans amid an exponential rise in COVID cases.”

Pick another country: “93% vaccinated Ireland has gone into partial lockdown, including midnight curfew.” This recent headline too, “COVID surge in Singapore despite 80 percent vaccination.” Or from the U.K. where the Spectator reported, “The rates of Covid infection per 100,000 are now higher among the vaxxed than the unvaxxed.”

Closer to home it’s much the same, “Vermont has the highest vaccination rate in the country. So why are cases surging?” My home state of Colorado is singing from the same hymnal, “Colorado’s COVID hospitalizations jump again as virus’ statewide death toll surpasses 9,000.” Colorado’s 12 and up population is over 80 percent partially or fully vaccinated.

If these numbers are misinformation, tell that to big media. I am quoting their headlines. Will their licenses be threatened?

Relationship between cases per 1 million people (last 7 days) and percentage of population fully vaccinated across 68 countries as of September 3, 2021

The CDC on its website claims, “Research provides evidence that COVID-19 vaccines are effective at preventing COVID-19.” Yet cases in highly vaccinated locations are surging, now almost two years into the COVID pandemic. As Billy Beane might say, “If the vaccines work, why aren’t they working?”

CV Vaccines Are Free

Last is the “free” claim. Nothing from the government is “free.” Recipients may not be charged but that is not the same as “free.” The government produces nothing and therefore is not able to offer anything for free. They confiscate money from those they lord over and redistribute it back to those from whom they took it.

The Pfizer vaccine costs the government about $20 per dose, with the other COVID vaccines in the same ballpark. Some 445 million doses of vaccine have been administered in the U.S. to date. That’s $9 billion right there. Spending on research and development has been estimated at $40 billion, pushing the total north of $50 billion, and likely much higher given the many hidden or non-transparent costs.

If these numbers seem off, major vaccine maker Pfizer expects $36 billion in COVID vaccine revenues in 2021, in the same range as the above numbers. While the vaccine may be free to the person getting jabbed, someone is paying the tab for the vaccine, syringe, and time of the person administering the shot. It always works that way – nothing is really “free.” As Billy Beane might say, “If the vaccines are free, why do they cost so much?”

There is nothing wrong with the medical establishment saying, “we don’t know” or “we’re not sure” about COVID prognostications, rather than being cocksure about everything until reality turns their pronouncements upside down. Gaslighting the public, being wrong more than right, doesn’t engender confidence.

Those who preach “follow the science” seem to neither understand nor desire to actually follow the science, instead letting politics replace science with our COVID policies often not following the science.

Dr. Anthony Fauci acknowledged the new vaccine reality in a New York Times podcast last Nov. 12,

“They are seeing a waning of immunity not only against infection but against hospitalization and to some extent death, which is starting to now involve all age groups. It isn’t just the elderly.”

When others observe and acknowledge this reality, they are ostracized and shamed. How long has Dr. Fauci known this? Last May, the CDC said that once vaccinated, you can return to a normal life. How is that working out?

Instead of transparency, we see this, “FDA wants 55 years to process FOIA request over vaccine data.” Is this, “part of the FDA’s commitment to transparency” as the FDA itself claims? This is the same FDA that took only 108 days to review Pfizer’s clinical trial data, deeming it safe and effective enough for FDA approval. But for the public, the FDA needs 20,000 days to “review” the same data before public release.

The published concept of “imperfect vaccinations enhancing the transmission of highly virulent pathogens,” meaning that vaccinating during a pandemic can create new vaccine-resistant virus strains, is never discussed. Neither are off-label therapeutics that while not a panacea, may save lives. Instead, the government and medical establishment balkanized the world, vaccinated versus unvaccinated, us versus them, the worthy versus the lepers, creating further division in an already divided society.

Despite the shaming and ridicule, here we are, almost two years into the COVID pandemic, with a mostly vaccinated population, and hospitals and ICUs are overrun with COVID cases. This pandemic should be in the rearview mirror, yet in some respects, it is bad as it was last year. Leaving Billy Beane to ask, “If the vaccines work, why aren’t they working?”

Footnote: A Major part of the answer is due to Mucosal Immunity

Ivermectin and the African Enigma

Double-click to enlarge image.

This post provides a synopsis of the PubMed paper COVID-19: The Ivermectin African Enigma. by R. Guerrero et al. (2020 Dec 30) Excerpts in italics with my bolds.

Overview

1) Why was this study conducted?
Ivermectin has been used since 1995 for the African Programme for Onchocerciasis Control (APOC). Currently, it is being considered as the possible target drug for SARS CoV-2. The low frequency of cases and deaths from the SARS-CoV-2 COVID-19 virus in some countries of Africa prompted us to assess the possible influence of this community-based strategy. (Note Onchocerciasis is commonly referred to as “river blindness.”)

2) What were the most relevant results of the study?
APOC Countries with a Community-directed treatment with ivermectin strategy show 28% lower mortality (RR= 0.72, 95% CI: 0.67-0.78) and 8% lower rate of infection (RR= 0.92, 95% CI: 0.91-0.93) due to COVID-19; compared with non-APOC countries.

3) What do these results contribute?
Our data suggest that a mass public health preventive campaign against COVID-19 may have taken place, inadvertently, in some African countries with massive community ivermectin use. Additional studies are needed to confirm it.

APOC is a partnership programme including 19 countries with active involvement of the Ministries of Health and their communities, several international and local NGDOs, the private sector (Merck & Co., Inc.), donor countries and UN agencies. The World Bank and WHO acted as Fiscal Agent as Executing Agency, respectively. A Community-Directed Treatment with Ivermectin was the delivery strategy of APOC. With the purpose of achieving sustainability, local communities were empowered to administer and distribute ivermectin in their own villages. The programme which was extended until 2015 intended to treat over 90 million people annually in the 19 countries, protecting an at risk population of 115 million, and to prevent over 40,000 cases of blindness every year 1,2. In 1998 the Program was expanded to some Asian countries to combat lymphatic filariasis and APOC countries continued to use ivermectin, in association with albendazole, in this program 3

We used generalized Poisson regression models to obtain effect estimates of APOC status on SARS-CoV-2 cumulative infection and mortality rates. The models included country characteristics to adjust for socioeconomic differences between countries that could affect their response capacity and quality to the pandemic. To measure the impact of confounding variables like health, education, and standard of living we decided to control them by using the Human Development Index (HDI)5. HDI is a geometric mean of normalized indices of the three key dimensions of human development: health, assessed by life expectancy at birth; education, measured by mean of years of schooling for adults aged ≥25 years and standard of living measured by gross national income per capita. Although it does not reflect poverty, security, empowerment, or inequalities, we consider that it is the best indicator that represents the global situation of a country.

Striking differences in the evolution of COVID-19 mortality are observed Figure 1B and APOC countries appear to have lower rates. Analysis of raw data, as shown in Table 1, indicate that APOC countries had lower infection (as indicated by lower case detection) and mortality rates due to COVID-19 (p <0.001). The ratio of mortality rates was 0.12 (95% CI: 0.12-0.13) and the ratio of infection rates was 0.16 (95% CI: 0.16-0.16), indicating that the APOC group was associated with lower mortality and infection rates compared to non-APOC countries, that is 88% and 84%, respectively. In addition, the APOC countries also had a lower number of detected cases and a lower frequency of tests.

Mortality, detection of new cases and number of tests performed were positively and significantly associated with HDI. The Figure 2 shows the COVID-19 Cumulative Mortality Rate per million in APOC countries compared with non-APOC countries.

Death rates were directly associated with HDI in all African countries, while number of infections were inversely associated in APOC countries, that is the higher the HDI the lower the expected number of infections. In African regions with HDIs above Z-score means, the expected number of deaths and infections was lower in APOC countries. In contrast, in the regions with the lowest HDI Z-score (less than 0), the estimated number of deaths and infections was lower in the non-APOC countries compared to APOC countries  (See Figure 15 at top).

No country knows with certainty the total number of subjects infected by SARS-CoV-2 within its territory, only an approximate number provided by the people who are tested; then, the number of tests performed largely determines the count of confirmed cases of the disease. In developed countries the number of tests performed can reach larger proportions of the population, like Iceland that had almost half of its population tested, 483 per thousand people7, however, on the African continent the tests performed per million inhabitants can be as low as in South Sudan 1,072 and Egypt 1,311 4.

A high HDI indicates longer life expectancy, better education and a higher standard of living. Our results coincide with others that show higher infections and death rates associated with high HDI 10,11. This can be explained because the component “life expectancy at birth is associated with a higher percentage of population >65 years. Our non-APOC group had a larger population in the >65 category and larger life expectancy (9 years) than the APOC group. That is why it is crucial to control for this confounding variable.

Mbow et al.12, analyzed the low morbi-mortality by COVID-19 in Africa compared to European countries and US, concluded that it is unlikely that it may be due to race, quality of reporting and death registration, different population age composition, lockdown stringency or other sociocultural aspects. Mbow mentions that studies of African COVID-19 patients show clear differences in the activation, proinflammatory and memory profiles of the immune cells compared not only versus Europeans but also among Africans with high and low exposure to microorganisms and parasites. Also suggest, that the virus may be spreading differently and with an attenuated outcome in Africa.

It is not known if a residual ivermectin effect increases the number of asymptomatic in the APOC countries. It is also unknown whether there are differences in susceptibility between populations of different African countries or regions. The ivermectin is considered a drug of choice for various parasitic and viral diseases and shown to have in vitro effects against SARS-CoV-2 13-16.  Although there have been suggestive clinical studies 17,18, and >50 trials are currently in progress worldwide 19. There is the need of good designed clinical trials to conclusively ascertain its benefits in humans.

Overall, the reasons are not clear, yet present data suggests that a mass public health preventive campaign against COVID-19 may have taken place, inadvertently, in some African countries with massive community ivermectin use.

For a more recent update on Ivermectin Covid effectiveness see Ivermectin Invictus: The Unsung Covid Victor

Covid The New State Religion

Tim O’Brien explains the rites and rituals in his American Thinker article COVID: A New State Religion?  Excerpts in italics with my bolds.

What started as a virus quickly became epidemic and then a global pandemic. The spread of a contagion laid the groundwork for what has become an industry, and it’s now morphing into a religious ideology with all of the familiar trappings.

That’s a total of $55.5 billion in vaccine sales for 2021 just from the three biggest providers of vaccine in the U.S. And this does not include a wide range of products, services, and industries that have cropped up to service the nation’s and the world’s COVID needs.

From makers of masks, cleaning supplies, hand sanitizer and ventilators, to major pharmacy companies paid millions to distribute vaccines, COVID has become a major industry.

Politicians and bureaucrats at the local, state, and federal level have seized on the COVID crisis to achieve unprecedented levels of power through vaccine mandates, lockdowns, restrictions, and of course, overnight changes to election procedures.

Then, there is the public health sector. These are its glory days. . .COVID is a new field of study, complete with federal grant moneys to analyze every aspect of COVID, so long as the research does not detract from the approved narrative.

COVID is an industry. It’s here and it’s not budging. But it’s more than that. It’s also an ideology with all of the accoutrements of an established religion.

The Baptism of Vaccination

The COVID vaccines are widely understood to be ineffective at preventing the spread of the virus. So, why the relentless emphasis on turning society on its head over flawed vaccines?

Like Christian baptism, the vaccine is the baptism into this new faith. The waters of baptism don’t physically clean one’s soul of sin any more than the vaccine can completely prevent contraction of COVID. In the ideological context, it’s a symbolic rite of passage into the faith.

Once injected, you can count yourself among the faithful, unlike the “unvaccinated” who are the COVID ideology’s equivalent to atheists circa 1400 A.D. It’s okay to shun them, demonize them, discriminate against them, even deny them life-saving healthcare. In fact, you have an obligation to do so, so they learn their lessons and step in line. Otherwise, they will be made an example.

It doesn’t matter that they may have their own religious objections, they may have personal medical histories, or they may even have natural immunity from the virus which is much more effective at preventing spread. What matters is that they can be dubbed “anti-vax,” a term that coincidentally or not sounds uncomfortably similar to “anti-Christ.”

To the faithful, if you’re unvaccinated for any reason, you’re selfish, you don’t care about others. You’re putting yourself before the majority, before the faith.

The Rites of COVID Ideology

Just as Catholicism has its rites in the form of seven sacraments, the COVID ideology does, too. One is the booster shot. If you were vaccinated a year ago, but have not yet gotten your booster shot, you are at risk of being labeled “unvaccinated” once again. Do you want to risk that?

Of course, once boosted, you have the privilege of knowing you are ‘born again.’

This new ideology even has the rite of confession. Were you asked by your employer, or the front office at the football stadium or basketball arena to disclose your vaccination status? How much different is that from the Catholic rite of reconciliation?

The practice of faith often involves sacrifice. The COVID ideology is not without sacrifice. Since adverse effects of the “safe and effective” vaccine are “extremely rare,” the burden is on you to take the risk. If you are one of those who contract chronic heart problems, permanent neurological disorders, or some other life-altering condition, that’s the sacrifice you must be willing to take for the good of the ideology.

COVID’s High Priests

Of course, no faith would be complete without its high priests, the most visible one being Dr. Anthony Fauci. He is routinely asked by leaders and journalists to bless one activity, behavior, or medical treatment over another. A legion of people seeks his final approval or disapproval on behaviors that until now were considered un-sinful. Some may even regard the pontifical bureaucrat as infallible.

He’s not alone. There is an army of COVID clergy with titles like “public health director,” “governor,” “mayor,” “human resources director,” “Silicon Valley billionaire,” “editor,” “producer” and “reporter” all of whom are the keepers of The Word when it comes to COVID. Each has front-line authority to make decisions on enforcement of COVID ideology.

To counter The Word or the narrative of this new faith is to be guilty of the sin of “misinformation,” punishable by banning, censorship, and denial of “communion” in the word’s most literal sense. The only way to regain access to the congregation is to recant.

If you belong to an established faith that holds dear the original Ten Commandments as handed down to Moses from God, you may recall the first one, which says, “I am the Lord your God. You shall have no other gods before me.”

Keep that in mind, because you may be asked to choose. The God of our fathers, or the god of COVID? Just know that the god of COVID is a jealous god.

 

Media Ignore Worldwide Revolt Against Covid Tyranny

Brownstone Institute compiled videos from around the world showing citizens protesting irrational restrictions imposed by Covid despots.  The article is Protests and Rage Against Lockdowns and Mandates All Over the World

As deadlines loom for mandatory vaccines, and the more lockdowns come to many countries of the world, people have taken to the streets in protest. In the typical case, local media either neglects to report on this or improperly characterizes them as “right wing” or “anti-vaxx.” It is likely that most people who get their news only from mainstream TV or The New York Times know nothing about what is happening.

The videos below, carefully chronicled by our friend Aaron Ginn, document what the media has neglected, even though this is the largest global protest movement to appear in decades. Keep in mind that this is only footage from select places from the last week. There are many more not appearing here and such protests have been building for more than a year.

These videos indicate the arrival of a turning point. Governments can continue to press these lockdowns and mandates against all scientific evidence and good public health or they can listen to the pains and anger of their own people.

Genova, Italy

Tbilisi, Georgia

London, England

Vancouver, Canada 

Melbourne, Australia

Northern Ireland 

Switzerland 

Vienna, Austria 

Linz, Austria

New Zealand 

Budapest, Hungary

New York City 

Croatia 

The Netherlands 

Toronto, Canada 

Denmark 

Oslo, Norway ​

Finland 

Manchester, England 

Milan, Italy 

Rome, Italy 

Turin, Italy 

Naples, Italy 

Florence, Italy 

Perth, Australia 

Brisbane, Australia 

Paris, France 

Nice, France 

Montpellier, France

Guadaloupe, Caribbean 

Greece 

Prague, Czech Republic 

Slovakia 

Germany 

Iran

Spain 

Oregon, USA 

Colombia 

To be continued…